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In 1961 the isotope carbon-12 was selected to replace oxygen as the standard relative to which the atomic weights of all the other elements are measured.

Carbon-14, which is radioactive, is the isotope used in radiocarbon dating and radiolabeling.

A notable example is the use of carbon-14 ( ..all the other elements combined.The radiocarbon age of a certain sample of unknown age can be determined by measuring its carbon 14 content and comparing the result to the carbon 14 activity in modern and background samples.The principal modern standard used by radiocarbon dating labs was the Oxalic Acid I obtained from the National Institute of Standards and Technology in Maryland. Around 95% of the radiocarbon activity of Oxalic Acid I is equal to the measured radiocarbon activity of the absolute radiocarbon standard—a wood in 1890 unaffected by fossil fuel effects.Accelerator mass spectrometry (AMS) is a modern radiocarbon dating method that is considered to be the more efficient way to measure radiocarbon content of a sample.In this method, the carbon 14 content is directly measured relative to the carbon 12 and carbon 13 present. Some inorganic matter, like a shell’s aragonite component, can also be dated as long as the mineral’s formation involved assimilation of carbon 14 in equilibrium with the atmosphere.

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